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One daily
serving of Grapefruit may increase
breast cancer risk in women by 30 % because of its estrogen-like effect.
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Long term use of antacid drugs
such as Ranitidine, Cimetidine and Famotidine, may cause cognitive impairment.
PPI such as pantoprazole, lanzoprazole
etc… are safe even for long periods of treatment.
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Despite its greatest
medical advances, the first super power has the 43rd life
expectancy in the world.
USA mortality is greater
than Jordan, Singapore or Guam.
Andorra in the French Pyrénées is the place on earth where man
lives longest.
Is it the indication of
the failure of the richest and most advanced medical system in the world?
Modification of drug law
is a priority: Every medicine has to prove its positive action against
mortality.
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Cardiologist in
the United States
1.3% are active smokers,
89% exercise regularly,
72% drink red wine at
least once a week.
4% have coronary
problems,
28% have dyslipidemia,
14% are hypertensive,
0.6% are
diabetics.
These
statistics show much better lifestyle among Cardiologists than general
population and even compared with other physicians.
Source
= Am J Cardiol 2006;97:1093-1096
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Early agressive statin therapy
: pretty simple to save lives
Less mortality, reinfarction,
and revascularization need
when Statins are
initiated during
the acute phase of an
ischemic event.
follow-up :15 months
aggressive statin
therapy : 25% risk reduction.
Source
= ACC 55th Annual
Scientific Session March 13, 2006 Abstract 821-5
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Sleep duration
Sleep duration between 6 and 8 hours at night
has a U-shaped distribution of risk concerning diabetes in men: risk of
diabetes increase by 2 % for less than 6 hours sleep duration and by 3 for
those men who sleep more than 8 hours.
Reminder: this sleep duration risk has been
reported previously for coronary heart disease, diabetes in women and all
cause mortality.
Source
= Diabetes Care 2006;29:657-661
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Methotrexate and chronic heart failure
Inflammatory mediators TNF-alpha, MCP-1, sICAM-1, and
CRP reduction by early low dose administration of methotrexate
for twelve weeks improve
symptoms and quality-of-life in chronic heart failure
patients.
Improvement occurs for NYHA functional class, 6-minute
walk test distance, and quality-of-life scores.
Source
= Am Heart J 2006;151:62-68
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Survival
in chronic heart failure.
Beta
blockers increase fat mass which seems to significantly improve survival in
CHF patients.
Source = Int J Cardiol
2006;106:319-322
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Less severe infection
with statins
Statins have
lipid-lowering
anti-inflammatory
antioxidant properties
endothelial function
improvement
cellular immunity
modulation
all that may contribute to
Reduced Sepsis Risk by 19 %.
Source
= the January 25th online issue of The Lancet
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Cardiovascular
events are linked to composition, morphology, and stability of plaque more
than the amount of atherosclerotic plaque.
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Statins’ anti-inflammatory and plaque-stabilising
properties reduce stroke incidence.
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High LDL cholesterol and
mortality risk:
In younger patients,
High LDL, high mortality
In elderly patients,
High LDL, lower mortality
Caution about LDL value
interpretation is required.
Source
= J Am Geriatr Soc 2005;53:2159-2164
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The ‘goal LDL’
concept is outdated.
Patients with an LDL
cholesterol level of 80 mg/dL or lower are at
29.0% risk of death, reinfarction, or stroke at
six months.
Same patients who were
discharged on statin therapy have 9.5% risk of death, reinfarction, or stroke at six months.
Source
: Am J Cardiol 2005;96:1491-1493
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The identification of
patients at risk for acute plaque rupture events may be possible in the
near future by reagents under development to detect overexpression
of activated MMP-9.
Source
= J Clin Invest 2005
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Alzheimer’s disease
patients have othostatic hypotension, low Heart
rate variability time because of autonomic cardiovascular dysfunction.
Source
= J Am Geriatr Soc 2005;53:2135-2139
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Although Blood Pressure
and cardiovascular mortality are lower in hot months and higher in cold
months, Blood Pressure is higher in
the elderly during hot weather nights.
Source
= Hypertension 2005;47
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Prevention of chemotherapy
chronic cardiotoxicity can be obtained by ARB.
Source
= Cancer 2005;104:2492-2498
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HSP60 and early carotid
atherosclerosis
sHSP60 and chronic infection
increase the risk of early atherogenesis.
Source = Stroke 2005;36:2571-2576
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Low meat and high
vegetable intakes prevent the development of elevated blood pressure.
Dairy consumption does
not have a consistent effect on blood pressure
Source
= Am J Clin Nutr
2005;82:1169-1177
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