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Zetia for treating cholesterol

A new drug approved recently by FDA to lower LDL cholesterol, Zetia, works by preventing the intestines from absorbing cholesterol. Associating Statins with this new drug possibly increases its efficacy by 25%.

Source = Schering-Plough Corp. and Merck and Co. Inc.

 

  

Taking double dose of Atorvastatin every other day reduces more your LDL cholesterol than taking one dose daily, thus reducing cost and increasing efficacy.

Source = Am Heart J. 2002;144:674-677

 

 

Simvastatin, a lipid lowering agent, may decrease hypertension in some rats.

Source = Hypertension 2002;40:142-147

 

 

A new cholesterol treating agent which increases good cholesterol (HDL) : the cholesteryl ester transfer protein inhibitor (CETP) .The results begin to appear the first week of treatment. No action on Triglycerides. No significant side-effects.

 Source = Circulation 2002;105  

 

 

Again and again,Statins seem good for Alzheimer's disease. Other anticholesterol agents have no effect on Alzheimer's disease.

Souce = American Academy of Neurology (AAN) 54th annual meeting

 

 

Low dose Niacin (50 mg /12h) for patients receiving statin (anticholesterol) therapy: More benefit by still HDL increase.

 Source = Am Heart J 2002;143:514-518

 

 

For cardiac patients:Do rest at least for 5 hours after a High-Fat Meal. Postprandial Angina mostly to occur 5 hours after High-Fat Meals (Significant dcrease in coronary flow and increase in Triglycerides).

 Source = Ann Intern Med 2002;136:523-528

 

 

Atorvastatin 80 mg per day (an intensive cholesterol-lowering therapy) lowers blood pressure and large arterry stiffness.

 Source = J Am Coll Cardiol 2002;39:1020-1025

 

 

Homocysteine damages brain tissueHigh levels related to silent brain infarcts and white matter cerebral lesions

 Source = Ann Neurol 2002;51:285-289.

 

 

Again, many differences between Statins properties and benefits:ATORVASTATIN v/s SIMVASTATINAtorvastatin better for treating  LDL, Triglycerides.Simvastatin for HDL

 Source = Am J Cardiol 2002;89:667-671.

 

 

Tumor necrosis factor-alpha (TNF-alpha) may be an early marker of coronary artery disease since it is found associated with high blood pressure, dyslipemia, triglyceride and LDL cholesterol.

 Source = Eur Heart J 2002;23:376-383.

 

 

Pharmacogenetics : COMING SOON in hormone replacement therapy (HRT): Gene testing for acurate indication of HRT. Genetic polymorphism explains significantly greater differences in HDL cholesterol  when treated with HRT especially HDL-3 which is the most important fraction of HDL.

 Source = N Engl J Med 2002;346:967-974.After

 

 

Significant drug-drug interactions : Avoid Simvastatin, use Pravastatin  with AIDS drugs : concentration values for simvastatin increased by 3,000%, atorvastatin by 79%, while pravastatin declined by 50%.

 Source = AIDS 2002;16:569-577.

 

 

The famous "anticholesterol" drug Pravastatin lowers Mortality in Patients With and Without cardiac disease !  collected data on 20,000 persons 5 years long : good evidence of benefit and safety .

 Source = Eur Heart J 2002;23:183-184,207-215              

 

 

Older white men and women have more coronary calcifications than older black men and women.High coronary artery calcium scores are : age, male sex, smoking, triglyceride levels and presences of cardiovascular disease.

 Source = Arterioscler Thromb Vasc Biol 2002;22:424-430